In the recent past the Masonry Infills are commonly used in RC Multi Storey Buildings. Masonry Infill?s are used as Equivalent Diagonal Strut. In the present study attempt has been made to study the effect of seismic loading in placing the Infill wall as Equivalent Diagonal Strut for the frame. In this study G+3,G+6,G+9 buildings with 4x4,5x5 and 6x6 Bays with Symmetrical Bay size and Unsymmetrical Bay size are been analyzed. All these models are been analyzed for 3 conditions: Bare Frame, Frame with Full Masonry Infill, and Frame with Soft Storey Infill. Linear Static Analysis is performed on these models to evaluate the seismic demand. The results are compared for Natural period, Storey Shear, Lateral Displacement and Storey Drift. Structural Analysis is carried out by using Extended Three Dimensional Analysis of Building Systems (ETABs) Version 9.6.0.