Reinforced concrete multi storey buildings are subjected to severe earthquakes. It was found that the main reason for failure of RC building is irregularity in its dimension and its lateral force resisting system. In this paper an analytical study is made to find response of different regular and vertical irregular structures such as mass, stiffness and geometry irregularity located in moderate zone III. Analysis has been made by taking 10 and 20 storey building by static and dynamic methods using ETABS 2013 and IS code 1893-2002 (part1). Behavior of structures will be found by comparing responses in the form of storey displacement, story drift and base shear for regular and vertical irregular structures. Different types of analysis methods such as equivalent static method, response spectrum and time history method are adopted. One is of regular structure and remaining are vertical irregular structural models. This paper shows that behavior vertical irregular structures as compared to regular structure.